diff options
author | Calvin Morrison <mutantturkey@gmail.com> | 2013-10-31 15:42:05 -0400 |
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committer | Calvin Morrison <mutantturkey@gmail.com> | 2013-10-31 15:42:05 -0400 |
commit | 8b543ec38690a7a41297fda56335b7f15cb0be8d (patch) | |
tree | c8e325566ba89568ab41d242a4d1c96c5bb4f441 /src/c/quikr_functions.c | |
parent | 87cf0208484b33d3194add9570b936998b44e9a3 (diff) |
finish up removing OCaml Code and general code refactoring
Diffstat (limited to 'src/c/quikr_functions.c')
-rw-r--r-- | src/c/quikr_functions.c | 155 |
1 files changed, 75 insertions, 80 deletions
diff --git a/src/c/quikr_functions.c b/src/c/quikr_functions.c index fab05ab..3697aa2 100644 --- a/src/c/quikr_functions.c +++ b/src/c/quikr_functions.c @@ -7,30 +7,30 @@ #include <unistd.h> #include <zlib.h> +#include "kmer_utils.h" #include "quikr.h" -unsigned long long count_sequences(const char *filename) { - char *line = NULL; - size_t len = 0; - ssize_t read; +void debug_arrays(double *count_matrix, struct matrix *sensing_matrix) { + FILE *count_fh = fopen("count.mat", "w"); + FILE *sensing_fh = fopen("sensing.mat", "w"); - unsigned long long sequences = 0; + unsigned long long width = pow_four(sensing_matrix->kmer); + unsigned long long i = 0; + unsigned long long j = 0; - FILE *fh = fopen(filename, "r"); - if(fh == NULL) { - fprintf(stderr, "could not open \"%s\"\n", filename ); - return 0; - } + for(i = 0; i < sensing_matrix->sequences; i++) { + for(j = 0; j < width - 1; j++) + fprintf(sensing_fh, "%lf\t", sensing_matrix->matrix[width*i + j]); + fprintf(sensing_fh, "%lf\n", sensing_matrix->matrix[width*i + width-1]); + } - while ((read = getline(&line, &len, fh)) != -1) { - if(line[0] == '>') - sequences++; - } + fclose(sensing_fh); - free(line); - fclose(fh); + for(j = 0; j < width - 1; j++) + fprintf(count_fh, "%lf\t", count_matrix[j]); + fprintf(count_fh, "%lf\n", count_matrix[width - 1]); - return sequences; + fclose(count_fh); } @@ -49,45 +49,56 @@ void normalize_matrix(double *matrix, unsigned long long height, unsigned long l } } +double *setup_count_matrix(char *filename, unsigned long long kmer, unsigned long long lambda, unsigned long long width) { -double *load_count_matrix(const char *filename, const unsigned long long width, const unsigned int kmer) { + unsigned long long x = 0; + unsigned long long *integer_counts = get_kmer_counts_from_file(filename, kmer); + double *count_matrix = malloc(width * sizeof(double)); + if(count_matrix == NULL) { + fprintf(stderr, "Could not allocate memory:\n"); + exit(EXIT_FAILURE); + } - double *count_matrix = malloc(width*sizeof(double)); - char count_command[1024]; - unsigned long long x = 0; + count_matrix[0] = 0; + + for(x = 1; x < width; x++) { + count_matrix[x] = (double)integer_counts[x-1]; + } + + free(integer_counts); + + // normalize our kmer counts + normalize_matrix(count_matrix, 1, width); + + // multiply our kmers frequency by lambda + for(x = 0; x < width; x++) + count_matrix[x] = count_matrix[x] * lambda; + + return count_matrix; +} + +unsigned long long count_sequences(const char *filename) { char *line = NULL; size_t len = 0; + ssize_t read; - if(count_matrix == NULL) { - fprintf(stderr, "could not allocate enough memory for the count matrix\n"); - exit(EXIT_FAILURE); - } + unsigned long long sequences = 0; - // create out count matrix - sprintf(count_command, "count-kmers -r %d -1 -u %s", kmer, filename); - FILE *count_output = popen(count_command, "r"); - if(count_output == NULL) { - fprintf(stderr, "could not execute \"%s\"", count_command); - exit(EXIT_FAILURE); + FILE *fh = fopen(filename, "r"); + if(fh == NULL) { + fprintf(stderr, "could not open \"%s\"\n", filename ); + return 0; } - // set first element to zero. - count_matrix[0] = 0; - - // get our first line - getline(&line, &len, count_output); - count_matrix[1] = atoi(line); - - // iterate over the rest of the lines - for(x = 2; x < width; x++) { - getline(&line, &len, count_output); - count_matrix[x] = atoi(line); - } + while ((read = getline(&line, &len, fh)) != -1) { + if(line[0] == '>') + sequences++; + } free(line); - pclose(count_output); + fclose(fh); - return count_matrix; + return sequences; } @@ -219,42 +230,26 @@ struct matrix *load_sensing_matrix(const char *filename) { return ret; } +struct matrix *setup_sensing_matrix(char *filename, unsigned long long kmer, unsigned long long lambda, unsigned long long width) { + unsigned long long x = 0; + unsigned long long y = 0; -char **load_headers(char *filename, long sequences) { - char command[512]; - char *line= NULL; - long x = 0; - FILE *grep_output; - size_t len = 0; - - sprintf(command, "grep ^\\> %s", filename); - grep_output = popen(command, "r"); - if(grep_output == NULL) { - fprintf(stderr, "Could not execute %s\n", command); - exit(EXIT_FAILURE); - } - - char **headers = malloc(sequences * sizeof(char *)); - if(headers == NULL) { - fprintf(stderr, "could not allocated enough memory\n"); - exit(EXIT_FAILURE); - } - - for(x = 0; x < sequences; x++) { - - char *header = malloc(256 * sizeof(char)); - if(header == NULL) { - fprintf(stderr, "could not allocated enough memory\n"); - exit(EXIT_FAILURE); - } - getline(&line, &len, grep_output); - sscanf(line + 1, "%s", header); - headers[x] = header; - } + struct matrix *sensing_matrix = load_sensing_matrix(filename); + if(sensing_matrix->kmer != kmer) { + fprintf(stderr, "The sensing_matrix was trained with a different kmer than your requested kmer\n"); + exit(EXIT_FAILURE); + } - free(line); - pclose(grep_output); + // multiply our sensing matrix by lambda + for(x = 1; x < sensing_matrix->sequences; x++) { + for(y = 0; y < width - 1; y++) { + sensing_matrix->matrix[width*x + y] = sensing_matrix->matrix[width*x + y] * lambda; + } + } - return headers; + // set the first column of our sensing matrix to 0 + for(x = 0; x < sensing_matrix->sequences; x++) { + sensing_matrix->matrix[width * x] = 1.0; + } + return sensing_matrix; } - |